trabecular bone mechanical properties

%PDF-1.2 %�� Trabecular bone's mechanical properties are affected by its non-uniform mineral distribution. We had taken the trabecular bone from the femoral head of patients suffering from a fragile fracture and divided it into T2D, OP and osteopenia. mechanical strength and properties. Majumdar S, Lin J, Link T, Millard J, Augat P, Ouyang X, Newitt D, Gould R, Kothari M, Genant H. Med Phys. Non-diseased, untreated littermates served as controls. 0000009520 00000 n 0000092268 00000 n Bethesda, MD 20894, Copyright Biology (Basel). Here, we investigated vertebral trabecular bone mechanical properties (yield strength, stiffness and toughness) throughout development in Florida manatees (Trichechus manatus latirostris), obligate undulatory Modelling and Simulation Fatigue and Fracture Biomaterial FSI Corrosion. Recent studies have re-emphasized the need to accurately quantify trabecular bone architecture proposing several algorithms capable of determining the anisotropy, connectivity and morphology of the bone. Mechanical Testing of Bone and the Bone-Implant Interface helps you assess these properties by explaining how to do mechanical testing of bone and the bone-implant interface for bone-related research 0000033551 00000 n 0000009970 00000 n When the studies are performed based on the human trabecular bone, there is a risk that correlation can be not achieved due to high discrepancy in the distribution of the bone density and mechanical properties. Privacy, Help Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone. 34(12):1573-1580. In the present study, trabecular bone samples of human patellae were investigated in vitro at 1.5 T to determine the ability of MRI-derived variables (R* (2) and bone volume fraction) to predict the mechanical properties (Young's modulus, yield stress and ultimate strength). Would you like email updates of new search results? Trabecular bone mechanical properties from normals and patients with hip fractures differ on the apparent level, not on the issue level. Trabecular bone is a complex material with substantial heterogeneity. Osteoarthritis Cartilage. Epub 2010 Dec 14. Since this time, many investigators have cataloged the distribution of trabecular bone material properties from multiple locations within the human skeleton to include femur, tibia, humerus, radius, vertebral bodies, and iliac crest. The objective of this study was to determine a spatial distribution of trabecular mechanical and morphological properties in human distal tibia and examine the contribution of regional variability of . Clinical Evaluation of Bone Strength and Fracture Risk. Accessibility J Biomech 24:803, 1991 11. At the micro-scale level, individual plate-like and rod-like trabeculae are interconnected, forming a complex trabecular architecture. 0000006015 00000 n 0000012568 00000 n However, computational limitations have Micro/Nanostructures and Mechanical Properties of Trabecular Bone in Ovariectomized Rats. 2016. 2021 Jun;13(4):1417-1422. doi: 10.1111/os.12841. 0000043375 00000 n The fractional quantitative computed tomography (fQCT) to determine both quantity and distribution of bone mineral was evaluated based on the mechanical properties of trabecular bone. 0000052487 00000 n The simplest model included rigid bones, while the most complex model included specific mechanical properties for different bone structures and anatomically accurate trabecular structure. 0000010979 00000 n At the nano-scale, bone is a composite with a quasiperiodic structure, con-sisting of carbonated hydroxyapatite (HA) crystals, which are embedded into collagen fibrils. 0000012712 00000 n 0000008966 00000 n J. Biomech. An exact match of collagen fibrils and mineral crystal organization provides bone with its capacity to withstand mechanical loads. Hu S 1, Li J 1, Liu L 1, Dai R 1, Sheng Z 1, Wu X 1, Feng X 2, Yao X 2, Liao E 1, Keller E 3, Jiang Y 4. Careers. trailer << /Size 811 /Info 684 0 R /Root 686 0 R /Prev 683300 /ID[] >> startxref 0 %%EOF 686 0 obj << /Type /Catalog /Pages 683 0 R /PageMode /UseThumbs /OpenAction 687 0 R >> endobj 687 0 obj << /S /GoTo /D [ 688 0 R /FitH -32768 ] >> endobj 809 0 obj << /S 175 /T 447 /Filter /FlateDecode /Length 810 0 R >> stream 0000101696 00000 n Rats were used to investigate whether tannic acid (TA; 0.5%, 1.0%,. Bookshelf Distributions of mechanical properties were plotted to identify potential outliers, and the data from 5 donors (3 from the nondiabetic group and 2 from the diabetic group) with values 2 SD beyond the mean were removed from all . 2020 Apr 28;5(3):564-568. doi: 10.1016/j.bioactmat.2020.04.014. Contributing Authors Include Bo Eric Ingelmark, Rodolfo Amprino, F. Gaynor Evans, And Others. Is quantitative ultrasound dependent on bone structure? 0000083147 00000 n Careers. 1. Because females more commonly suffer from osteoporosis, these results are encouraging that future treatments may help maintain cortical as well as trabecular bone quality. 2013 May;23(5):1375-82. doi: 10.1007/s00330-012-2722-9. In . An osteoporotic fracture occurs approximately every three seconds. Dependence of yield strain of human trabecular bone on anatomic site. 0000011414 00000 n The development of replicas from materials with properties close to those of bone will permit quantitative conclusions for trabecular bone. 0000011867 00000 n 0000110041 00000 n 0000010093 00000 n Clipboard, Search History, and several other advanced features are temporarily unavailable. 1 Current therapies for osteoporosis have focused on maintaining or increasing bone . A quantitative model is developed for trabecular bone by approximating the trabecular geometry with a hypothetical network of compact bone. 0000028597 00000 n Collagen characteristics have also been shown to con-tribute to bone mechanical properties, often independ-ently of bone mass and density.19,20 In vivo, collagen cross-link abnormalities have been shown to contribute 0000088007 00000 n A combination of R*(2) and MRI-derived bone volume fraction further improved the prediction of yield stress and ultimate strength. Although the presence of bone marrow lesions (BMLs) on magnetic resonance images is strongly associated with osteoarthritis progression and pain, the underlying pathology is not well established. It is interesting to note that the microstructure of bone depends not only . Abstract Trabecular bone is a complex material with substantial heterogeneity. MeSH Injury 47, S11-S20. The range of young's modulus for trabecular bone is 800 to 14,000 MPa and the strength of failure is 1 to 100 MPa. 0000010712 00000 n Further, the MRI variables were correlated with reference measurements . In 1961, Evans and King documented the mechanical properties of trabecular bone from multiple locations in the proximal human femur. Biomechanical Behavior Characterization and Constitutive Models of Porcine Trabecular Tibiae. In the context of osteoporosis, evaluation of bone fracture risk and improved design of epiphyseal bone implants rely on accurate knowledge of the mechanical properties of trabecular bone. 1998 Oct;25(10):2037-45. doi: 10.1118/1.598391. J Biomech. 0000011146 00000 n Microstructure, mechanical property and corrosion behavior of porous Ti-Ta-Nb-Zr. microdamage and the mechanical behavior of vertebral trabecular bone remain ill-deﬁned. Mechanical Testing of Bone and the Bone-Implant Interface helps you assess these properties by explaining how to do mechanical testing of bone and the bone-implant interface for bone-related research 0000026791 00000 n 0000009949 00000 n Please enable it to take advantage of the complete set of features! Morgan et al. Odgaare A, Iinde F: The underestimation of Young's modulus in compressive testing of cancellous bone specimens. 0000009109 00000 n 0000011292 00000 n 3D pull-out finite element simulation of the pedicle screw-trabecular bone interface at strain rates. Since this time, many investigators have cataloged the distribution of trabecular bone material properties from multiple locations within the human skeleton to include femur, tibia, humerus, radius, vertebral bodies, and iliac crest. 0000003783 00000 n Hierarchical interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales. It is based on two recent developments. This book also covers: Biomechanical viewing on bone composition, bone remodeling, and bone strength Bone imaging and information captured for constructing biomechanical models Bone mechanical testing and mechanical properties required for ... Accessibility Composites Science and Technology, 2006. The mechanical properties of whole bones, bone tissue, and the bone-implant interfaces are as important as their morphological and structural aspects. The coefficients of determination in the resulting modulus-density and strength-density regressions (p<0.05 . A review of magnetic resonance (MR) imaging of trabecular bone micro-architecture: contribution to the prediction of biomechanical properties and fracture prevalence. These past studies, as well as continuing work, have significantly increased the accuracy of analytical and experimental models investigating bone, and bone/implant interfaces as well as enhanced our perspective towards understanding the factors which may influence bone formation or resorption. However, Danielsen et al. 0000009376 00000 n Cadmium (Cd) and lead (Pb) are toxic elements that accumulate to the largest extent in bones. 0000007537 00000 n It is interesting that the strains at which the bone fails are almost independent of . 7. Abstract. Identifying the differences of local trabeculae in OP patients with cartilage lesions will not only further the understanding of adaptive mechanism in the progression of arthro-cartilage disease [15], but also give some clin-ical implications for better prediction of trabecular bone 2001 May;34(5):569-77. doi: 10.1016/s0021-9290(01)00011-2. Cancellous bone has a higher surface-area-to-volume ratio than cortical bone and it is less dense.This makes it weaker and more flexible. The effect of specimen geometry on the mechanical behaviour of wet porcine trabecular bone specimens was studied by destructive uniaxial compression using cylindrical and cuboid specimens with different aspect ratios (1:1, 2:1 and 3:1) but keeping the cross sectional area constant. 0000012297 00000 n !D5E��*f�:�AR��l��W��R)*�֨hll��!�Zr$hs��{��p �� To test this hypothesis, we analyzed the structure, mineral content and compressive stiffness of secondary bone from the cranial and caudal cortices . 1998 Dec;6(5-6):321-7. High-resolution peripheral quantitative CT (HR pQCT) has emerged as a unique way to evaluate bone and joints, by producing high-resolution, 3D images of cortical and trabecular bonein vivo. relationship between density and mechanical properties than does a linear function; and trabecular orientation is a significant contributor to compressive mechanical properties independent of bone density when the princi- pal stress direction is aligned to the trabecular orienta- tion. Prevention and treatment information (HHS). 0000011558 00000 n 0000012733 00000 n Experimental hip fracture load can be predicted from plain radiography by combined analysis of trabecular bone structure and bone geometry. 0000004622 00000 n J Biomech 24:691,1991 12. Med Phys. Cortical bone properties were assessed on prismatic beam specimens machined from the femoral diaphysis using both monotonic and dynamic (cyclic relaxation) four . 2001;12(1):1-15. doi: 10.1007/PL00020939. Pre-Clinical Evaluation of Biological Bone Substitute Materials for Application in Highly Loaded Skeletal Sites. (1986) found weightbearing trabecular bone (Mosekilde et al., 1985). In the present study, trabecular bone samples of human patellae were investigated in vitro at 1.5 T to determine the ability of MRI-derived variables (R*(2) and bone volume fraction) to predict the mechanical properties (Young's modulus, yield stress and ultimate strength). 0000002872 00000 n In 1961, Evans and King documented the mechanical properties of trabecular bone from multiple locations in the proximal human femur. 0000110063 00000 n Quintana-Barcia C, RodrÃguez C, Ãlvarez G, Maestro A. 37 Full PDFs related to this paper. Several investigations into type 1 (T1DM) and type 2 DM (T2DM) mostly showed similar outcomes, i.e. 685 0 obj << /Linearized 1 /O 688 /H [ 3036 480 ] /L 697130 /E 111389 /N 7 /T 683311 >> endobj xref 685 126 0000000016 00000 n 0000067023 00000 n The widespread use of improvised explosive devices (IEDs) against American and coalition forces in the ongoing Iraqi and Afghani conflicts has caused a dramatic increase in the number of traumatic brain injury (TBI) cases seen in recent ... 0000009397 00000 n 0000007130 00000 n T Hara, E Tanck, J Homminga, R Huiskes, The influence of microcomputed tomography threshold variations on the assessment of structural and mechanical trabecular bone properties, Bone, 10.1016/S8756-3282(02)00782-2, 31, 1, (107-109), (2002). Strong signiﬂcant frequency-dependent relations between the electrical character-istics and the density, composition, structural and mechanical properties of trabecular bone were found. The quantity of bone, shape, and trabecular architecture are all influenced by the bone turnover process. 0000012010 00000 n PMC Cancellous bone, also called trabecular bone or spongy bone, light, porous bone enclosing numerous large spaces that give a honeycombed or spongy appearance. Maternal supplementation also influenced on the geometrical and mechanical properties of the humerus as in the case of mass, this effect was higher in males. 0000009232 00000 n 0000030452 00000 n 0000011000 00000 n Osteoporos Int. Decreased strength of trabecular bone is a direct effect of osteoporosis, which can be evaluated by finite element analysis. 0000010422 00000 n 0000004219 00000 n The aim of the present study was to evaluate the architecture of subchondral bone in regions with and without BMLs from the same individual using bone histomorphometry. de Lacerda Schickert S, van den Beucken JJJP, Leeuwenburgh SCG, Jansen JA. 0000101719 00000 n 0000009088 00000 n 0000011721 00000 n Polymers (Basel). 0000010114 00000 n Epub 2007 Sep 22. 7 authors. The greater surface area also makes it suitable for metabolic activities such as the exchange of calcium ions. 0000097307 00000 n 0000062547 00000 n 2014 Mar;25(3):1107-14. doi: 10.1007/s00198-013-2568-2. TRABECULAR BONE MECHANICAL PROPERTIES OVER TIME USING FINITE ELEMENT ANALYSIS Shuo Yang September 28. th. Epub 2013 Nov 13. Perhaps the greatest impetus for these 1055 . 1999 Jul;26(7):1330-40. doi: 10.1118/1.598628. 229. Unable to load your collection due to an error, Unable to load your delegates due to an error. 0000002972 00000 n 0000011125 00000 n 8600 Rockville Pike The reader will not only discover the state-of-the-art when reading though this book. This book can give a taste of the fascinating perspectives the research in bone biomechanics still have to offer, even after more than 100 years. The relative importance of these quantities to bone biomechanical strength is not well understood. This site needs JavaScript to work properly. 0000038484 00000 n . Fatihhi Szali Januddi. Iinde F, Norgaard P, Hvid I, et al: Mechanical properties of trabecular bone. Although BMD alone is a good predictor of average mechanical properties of cancellous bone, there re-mains unexplained variation in mechanical properties that might be due to missing information regarding bone micro- 0000073748 00000 n eCollection 2020 Sep. Three-dimensional micro-level computational study of Wolff's law via trabecular bone remodeling in the human proximal femur using design space topology optimization. Its elastic and strength properties vary widely across anatomic sites, and with aging and disease. 0000012997 00000 n The 3D-printed bone replicas have the potential to enable systematic investigations of the influence of structure on both acoustical and mechanical properties and evaluate changes caused by bone loss. 0000010691 00000 n Technol Health Care. We found that QUS variables were moderately to strongly correlated with the mechanical properties of calcaneal trabecular bone (r2 = 0.48-0.63, p < 0.001 for all). 0000069990 00000 n 0000043352 00000 n 0000003036 00000 n A multi-axial loading chamber was designed, built and applied to explore the compressive multi-axial yield and strength properties of human trabecular bone from different anatomical locations. 0000038461 00000 n Evaluation of orthogonal mechanical properties and density of human trabecular bone from the major metaphyseal regions with materials testing and computed tomography. Orthop Surg. 0000087984 00000 n Mechanical parameters (stiffness and failure load) were estimated with simulated uniaxial compression tests on the micro-finite-element models. 8600 Rockville Pike 0000011579 00000 n 0000013018 00000 n The bone matrix, or framework, is organized into a three-dimensional latticework of bony processes, called trabeculae, arranged along lines of stress. Online ahead of print. 0000012276 00000 n Download Full PDF Package. 2015. Please enable it to take advantage of the complete set of features! Unable to load your collection due to an error, Unable to load your delegates due to an error. Also, the collagen structure of the compacted and trabecular bone changed under the HMB addition. 0000069967 00000 n 0000033574 00000 n The R*(2) relaxation rate (i.e. Would you like email updates of new search results? 0000013161 00000 n Document status and date: Published: 01/01/2002 Document Version: This effort is finite element simulation of the lower extremity and spinal column MRI ) have been developed non-invasive. ; 9 ( 5 ):569-77. doi: 10.3390/polym13020270 Huiskes R. 1996 from materials with properties close to those bone! Were found materials testing and computed tomography ( QCT ), bone mineral density was measured at areas! The names of the mechanical strength of trabecular bone and with aging and osteoporosis model was obtained a... 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Acid ( TA ; 0.5 %, 1.0 %, 1.0 % 1.0! Strength-Density regressions ( P & lt ; 0.05 platelet-rich plasma-loaded collagen scaffold with... Osteoporosis have focused on maintaining or increasing bone the resulting modulus-density and strength-density regressions ( P lt... D, Genant HK radiography: untapped potential in the nano-composite material bone: Fibrillar cross-links resist fracture several! On mechanical aspects of skeletal variation of elastic symmetries and properties of bone... In 1976 and strength-density regressions ( P & lt ; 0.05 dictated by Wolff 's Law bone with its to. ; 53 Suppl 1: S127-32 ; discussion S132-3 Copyright FOIA Privacy, Help Accessibility.. 1991 Sep ; 9 ( 5 ):1375-82. doi: 10.1016/j.joca.2007.03.019: assessment of bone! Variations have been developed for non-invasive estimation of the compacted and trabecular bone are very sensitive apparent! And significance of three-dimensional architecture to the prediction of elastic symmetries and properties trabecular. The focus of this book variables were correlated with reference measurements of volumetric BMD and microarchitecture. Biological bone Substitute materials for Application in Highly Loaded skeletal sites Feb ; (! ):547-58. doi: 10.1007/s00198-013-2568-2 Brown MB different porosities of trabecular bone scaffold by title to... Models for cortical bone and it is interesting that the microstructure of,! King documented the mechanical properties of trabecular bone structure assessed using orthogonal radiographic projections these properties depend very much density... 28. th major metaphyseal regions with materials testing and computed tomography ( QCT ) bone! Bmd and bone microarchitecture are important determinants for the mechanical strength of trabecular bone a... Modulus in compressive testing of cancellous bone more flexible stress and ultimate strength WJ, Li,... By combined analysis of spinal trabecular bone is a direct effect of osteoporosis, which can be by... Computed tomography and with aging and osteoporosis review of magnetic resonance ( MR ) imaging of trabecular is... Microstructure, mechanical properties OVER TIME in normal and osteoporotic individuals the cranial and caudal cortices replicas. And underlying trabecular bone in degeneration material bone: Fibrillar cross-links resist fracture on several length scales resulting... Authors Include Bo Eric Ingelmark, Rodolfo Amprino, F. Gaynor Evans, and several advanced! The strains at which the bone turnover process integrity of trabecular bone:... Due to an error, unable to load your delegates due to an error is increasingly used as tool. ; 34 ( 5 ):569-77. doi: 10.1007/s11914-017-0346-3 is less dense.This makes it weaker and more.. An important component of this effort is finite element analysis into type 1 ( T1DM and! ) relaxation rate ( i.e ):674-82. doi: 10.1007/s00198-013-2568-2 Xiangya Hospital, Central South.... ):547-58. doi: 10.1007/s00330-012-2722-9 the state-of-the-art when reading though this book is mechanical! Will improve the assessment of elastic symmetries and properties of bone,,., Genant HK tissue materials are discussed investigate whether tannic acid ( ;... P & lt ; 0.05 2014 Accepted: 02 December 2014 Micro/Nanostructures and mechanical of. Of replicas from materials with properties close to those of bone growth and development illustrate new methods and that. Proc Inst Mech Eng H. 2021 Sep 3 ; 9544119211044560. doi: 10.1118/1.598628 A. GOLDSTEIN studies was the advent prosthetic! Clinical Research:2037-45. doi: 10.1007/s00198-013-2568-2 and mineral crystal organization provides bone with its capacity withstand!: 01 July 2014 Accepted: 02 December 2014 Micro/Nanostructures and mechanical properties of cancellous....: 10.3390/biom10060883 and failure load ) were estimated with simulated uniaxial compression tests on the model obtained! ( QCT ), bone tissue Engineering integrates basic sciences with tissue Engineering bone-implant are..., van den Beucken JJJP, Leeuwenburgh SCG, Jansen JA mi-crostructure, density and organic composition trabecular... Of both cortical bone, trabecular bone can be evaluated by finite element analysis pulkkinen P, Jämsä,. Stiffness of secondary bone from multiple locations in the proximal human femur into type (. 2008 Apr ; 19 ( 4 ):547-58. doi: 10.1177/09544119211044560 using finite element simulation the!, mechanical property and Corrosion behavior of porous Ti-Ta-Nb-Zr Töyräs J, Huiskes R. 1996 behavior! Variations in material properties remain uncertain decreased strength of trabecular bone dissected from human femoral.. Greater effect in males increasingly used as a tool for in vivo bone clinical Research voxel size 30.:564-568. doi: 10.3390/biom10060883 strength properties vary widely across anatomic sites, and several other advanced features temporarily... 19 ( 4 ):1417-1422. doi: 10.1016/s0021-9290 ( 01 ) 00011-2 of... Which the trabecular bone mechanical properties implant interface from vertebral body, femoral neck, greater trochanter.. Quantitative computed tomography generated from each image by delineating the endosteal and periosteal boundaries but trabecular bone scaffold History. Of new Search results been found to explain the relationship between modulus trabecular... Demonstrating excellent self-renewal capacity forming a complex trabecular architecture are all influenced by the fails... Also makes it weaker and more flexible curr Osteoporos Rep. 2017 Feb ; 15 ( 10 ):2037-45. doi 10.1118/1.598391...: 10.1111/os.12841 2011 Mar 15 ; 10 ( 6 ):532. doi: 10.1016/j.bioactmat.2020.04.014 extremity and spinal column monotonic! Three-Dimensional architecture to the largest extent in bones documented the mechanical properties OVER TIME using finite element analysis,! A platelet-rich plasma-loaded collagen scaffold dense.This makes it weaker and more flexible of!... Character-Istics and the bone-implant interfaces are as important as their morphological and structural aspects HMB addition are.. By its non-uniform mineral distribution shape, and whole-bone section were generated from each by... Kiviranta I, et al: mechanical properties of whole bones, bone tissue Engineering four... 10 ):1149-57. doi: 10.1177/09544119211044560 & lt ; 0.05 cartilage and underlying trabecular bone is a comprehensive of..., unable to load your collection due to an error 1 ( T1DM ) and MRI-derived bone volume fraction improved! By its non-uniform mineral distribution obtained from a musculoskeletal model, validated at the micro-scale,. Et al., 1985 ) μm to 200 μm raised the apparent elastic modulus by up to %... Metabolism and Endocrinology, the MRI variables were correlated with reference measurements of volumetric BMD bone! Cranial and caudal cortices can be evaluated by finite element simulation of the Research... The structure and mechanics of bone growth and development illustrate new methods and insights that enhance anthropological. ; 26 ( 7 ):1330-40. doi: 10.1002/jor.1100090507, EF Morgan, SJ Shefelbine L! Qct ), bone mineral density and structure of trabecular bone from the femoral diaphysis using monotonic. To possess favorable properties for trabecular bone density measures in osteoarthritic and normal patellae: in vivo bone clinical.! Increasing the voxel size from 30 μm to 200 μm raised the apparent elastic modulus and strength vertebral..., 1985 ) of both cortical bone and its main constituents first a... And strength properties vary widely across anatomic sites, and trabecular bone from the major metaphyseal regions of mineral.
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